Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 2/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.34 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | CASP1 | P29466 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9568596 | 0.78 | DHFR (0.49) | BRPF1PRKCIKDM4ECHEK1AURKA | |
| SCHEMBL12803632 | 0.75 | CYP11B2 (0.38) | BRPF1KDM4EALDH1A1MAPTCYP2A6 | |
| SCHEMBL31036167 | 0.73 | BRPF1 (0.62) | BRPF1PRKCIKDM4EALDH1A1MAPT | |
| SCHEMBL3481207 | 0.73 | BRPF1 (0.62) | BRPF1PRKCIKDM4EALDH1A1MAPT | |
| SCHEMBL12967738 | 0.73 | BRPF1 (0.45) | BRPF1PRKCIKDM4ECHEK1AURKA | |
| Hydrochloric Acid SCHEMBL27614396 | 0.72 | BRPF1 (0.61) | BRPF1PRKCIKDM4ERAD52ALDH1A1 | |
| SCHEMBL21983451 | 0.70 | CYP2A6 (0.39) | KDM4EALDH1A1MAPTCYP2A6TDP1 | |
| SCHEMBL22421773 | 0.68 | BRPF1 (0.64) | BRPF1PRKCIKDM4ECHEK1AURKA | |
| SCHEMBL23926495 | 0.67 | BRPF1 (0.44) | BRPF1PRKCIKDM4ECHEK1AURKA | |
| SCHEMBL12967997 | 0.67 | PRKCI (0.53) | BRPF1PRKCIKDM4ECHEK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012131031-A1 | NEW POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR | H. LUNDBECK A/S (DK) | 2012-10-04 | — | — | WO | disclosed |