Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 1.00 |
| ▸ | TNNI3K | Q59H18 | 6/20 | 0.73 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.64 |
| ▸ | BRAF | P15056 | 3/20 | 0.62 |
| ▸ | TOP2A | P11388 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | SRC | P12931 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | MET | P08581 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.56 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.56 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL12813002 | 0.99 | ROCK1 (0.97) | ROCK1TNNI3KMKNK1BRAFTOP2A | |
| SCHEMBL12969352 | 0.82 | ROCK1 (0.69) | ROCK1TNNI3KBRAFSRCABL1 | |
| Hydrochloric Acid SCHEMBL12813276 | 0.81 | ROCK1 (0.67) | ROCK1TNNI3KBRAFSRCABL1 | |
| SCHEMBL15834293 | 0.81 | ROCK1 (0.67) | ROCK1TNNI3KSRCABL1EGFR | |
| SCHEMBL4926098 | 0.79 | MKNK1 (0.73) | ROCK1TNNI3KMKNK1BRAFTOP2A | |
| SCHEMBL4923804 | 0.79 | MKNK1 (0.73) | ROCK1MKNK1BRAFTOP2ANPC1 | |
| SCHEMBL4921641 | 0.79 | MKNK1 (0.73) | ROCK1MKNK1BRAFTOP2ANPC1 | |
| SCHEMBL4922517 | 0.79 | MKNK1 (1.00) | ROCK1MKNK1BRAFTOP2ANPC1 | |
| SCHEMBL4923460 | 0.78 | ROCK1 (0.64) | ROCK1MKNK1BRAFTOP2ANPC1 | |
| SCHEMBL1060507 | 0.78 | MKNK1 (0.72) | ROCK1TNNI3KMKNK1BRAFTOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9616064-B2 | Rho kinase inhibitors and methods of use | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-04-11 | — | — | US | disclosed |
| US-9616064-B2 | Rho kinase inhibitors and methods of use | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-04-11 | — | — | US | disclosed |
| US-20140179689-A1 | NOVEL RHO KINASE INHIBITORS AND METHODS OF USE | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| US-20140179689-A1 | NOVEL RHO KINASE INHIBITORS AND METHODS OF USE | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| WO-2012135697-A2 | NOVEL RHO KINASE INHIBITORS AND METHODS OF USE | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE INC. (US) | 2012-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179689-A1 | NOVEL RHO KINASE INHIBITORS AND METHODS OF USE | ROCK1, ROCK2, RHOA | ROCK1 1/4885TNNI3K 281/4885MKNK1 278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.