Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.67 |
| ▸ | SRC | P12931 | 3/20 | 0.63 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.62 |
| ▸ | MET | P08581 | 1/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.62 |
| ▸ | KIT | P10721 | 1/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.62 |
| ▸ | FLT1 | P17948 | 1/20 | 0.62 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.62 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.62 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | CDK2 | P24941 | 15/20 | 0.60 |
| ▸ | NEK2 | P51955 | 2/20 | 0.60 |
| ▸ | CDK1 | P06493 | 6/20 | 0.57 |
| ▸ | CDK9 | P50750 | 5/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.57 |
| ▸ | CDK7 | P50613 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12969352 | 0.86 | ROCK1 (0.69) | ROCK1SRCABL1EGFRERBB2 | |
| Hydrochloric Acid SCHEMBL12813276 | 0.85 | ROCK1 (0.67) | ROCK1SRCABL1EGFRERBB2 | |
| SCHEMBL12968947 | 0.81 | ROCK1 (1.00) | ROCK1SRCABL1EGFRERBB2 | |
| SCHEMBL16146768 | 0.80 | SRC (0.59) | SRC | |
| SCHEMBL16145741 | 0.80 | MKNK1 (0.63) | CHEK1 | |
| SCHEMBL16146838 | 0.80 | SRC (0.59) | SRC | |
| SCHEMBL11015321 | 0.80 | SRC (0.56) | SRCCDK2 | |
| Hydrochloric Acid SCHEMBL12813002 | 0.80 | ROCK1 (0.97) | ROCK1SRCABL1EGFRERBB2 | |
| SCHEMBL30434006 | 0.74 | ADORA3 (0.55) | — | |
| SCHEMBL29822351 | 0.73 | ADORA3 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9616064-B2 | Rho kinase inhibitors and methods of use | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-04-11 | — | — | US | disclosed |
| US-20140179689-A1 | NOVEL RHO KINASE INHIBITORS AND METHODS OF USE | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2014-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179689-A1 | NOVEL RHO KINASE INHIBITORS AND METHODS OF USE | ROCK1, ROCK2, RHOA | ROCK1 1/4885SRC 137/4885ABL1 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.