Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C3AR1 | Q16581 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSG | P08311 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16602128 | 0.90 | C3AR1 (0.49) | C3AR1ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL800754 | 0.89 | C3AR1 (0.42) | C3AR1ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL12980639 | 0.89 | C3AR1 (0.46) | C3AR1ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL5014051 | 0.85 | ALDH1A1 (0.58) | C3AR1ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL12493298 | 0.84 | C3AR1 (0.47) | C3AR1ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL22636117 | 0.84 | C3AR1 (0.62) | C3AR1ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL22636119 | 0.84 | C3AR1 (0.62) | C3AR1ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL15214453 | 0.83 | C3AR1 (0.43) | C3AR1ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL800492 | 0.83 | KMT2A (0.49) | C3AR1ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL12979837 | 0.83 | C3AR1 (0.43) | C3AR1ALDH1A1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2518056-B1 | SEVEN-MEMBERED RING COMPOUND AND PHARMACEUTICAL USE THEREFOR | DAIICHI SANKYO CO LTD (JP) | 2015-07-29 | — | — | EP | disclosed |
| US-8846660-B2 | Seven-membered ring compound and pharmaceutical use therefor | DAIICHI SANKYO COMPANY, LTD. (JP) | 2014-09-30 | — | — | US | disclosed |
| EP-2518056-A1 | SEVEN-MEMBERED RING COMPOUND AND PHARMACEUTICAL USE THEREFOR | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-10-31 | — | — | EP | disclosed |
| US-20120259111-A1 | SEVEN-MEMBERED RING COMPOUND AND PHARMACEUTICAL USE THEREFOR | DAIICHI SANKYO COMPANY LIMITED (JP) | 2012-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120259111-A1 | SEVEN-MEMBERED RING COMPOUND AND PHARMACEUTICAL USE THEREFOR | CMA1, CPA3, TMPRSS15 | C3AR1 294/4885ALDH1A1 2094/4885TSHR 4211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.