⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2319664 | 0.85 | ALDH1A1 (0.42) | — | |
| SCHEMBL5762176 | 0.81 | ALDH1A1 (0.42) | — | |
| SCHEMBL14934920 | 0.81 | ALDH1A1 (0.46) | — | |
| SCHEMBL2085613 | 0.80 | FAAH (0.47) | — | |
| SCHEMBL5177417 | 0.80 | HCAR2 (0.39) | — | |
| SCHEMBL10689235 | 0.80 | NPSR1 (0.50) | — | |
| SCHEMBL10689237 | 0.80 | NPSR1 (0.50) | — | |
| SCHEMBL4807770 | 0.78 | MAPT (0.39) | — | |
| SCHEMBL4812377 | 0.78 | MAPT (0.39) | — | |
| SCHEMBL18501522 | 0.78 | MAPT (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114890932-A | First total synthesis process of indole alkaloid Luteoride A | 大理大学 | 2022-08-12 | — | — | CN | claimed |
| JP-56061328-A | — | — | None | — | — | JP | disclosed |
| US-20160332971-A1 | ARYLQUINOLINE, ARYLQUINOLONE AND ARYLTHIOQUINOLONE DERIVATIVES AND USE THEREOF TO TREAT CANCER | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2016-11-17 | — | — | US | disclosed |
| US-8889691-B2 | Indole compounds as an inhibitor of cellular necrosis | LG LIFE SCIENCES LTD. (KR) | 2014-11-18 | — | — | US | disclosed |
| US-20140024618-A1 | INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2014-01-23 | — | — | US | disclosed |
| US-8569307-B2 | Indole compounds as an inhibitor of cellular necrosis | LG LIFE SCIENCES LTD. (KR) | 2013-10-29 | — | — | US | disclosed |
| EP-2178869-B1 | INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD (KR) | 2013-06-12 | — | — | EP | disclosed |
| WO-2013045495-A1 | PYRANO[3,2-c][2]BENZOPYRAN-6(2H)-ONE DERIVATIVES AND USES THEREOF | PROUS INSTITUTE FOR BIOMEDICAL RESEARCH, S.A. (ES) | 2013-04-04 | — | — | WO | disclosed |
| EP-2573088-A1 | Pyrano[3,2-c]benzopyran-6(2h)-one derivatives and uses thereof | Prous Institute for Biomedical Research, S.A. (ES) | 2013-03-27 | — | — | EP | disclosed |
| US-8404677-B2 | Kinase inhibitors | GENOSCO (US) | 2013-03-26 | — | — | US | disclosed |
| WO-2008014311-A2 | INHIBITORS OF UNDECAPRENYL PYROPHOSPHATE SYNTHASE | NOVARTIS AG (CH) | 2008-01-31 | — | — | WO | disclosed |
| EP-1786411-A2 | 3-HALO-2-OXOPROPIONATE SALTS AND ESTERS AS NOVEL ANTICANCER AGENTS | Board of Regents, The University of Texas System (US) | 2007-05-23 | — | — | EP | disclosed |
| US-20060287356-A1 | dietetics or antidiabetic agents such as 4-hydroxy-3-(4'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile, used for prophylaxis of metabolic disorders | IYENGAR RAJESH R | 2006-12-21 | — | — | US | disclosed |
| US-7119205-B2 | Thienopyridones as AMPK activators for the treatment of diabetes and obesity | ABBOTT LABORATORIES (US) | 2006-10-10 | — | — | US | disclosed |
| US-20060058383-A1 | Propyl 3-bromo-2-oxopropionate and derivatives as novel anticancer agents | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2006-03-16 | — | — | US | disclosed |
| WO-2006020403-A2 | 3-HALO-2-OXOPROPIONATE SALTS AND ESTERS AS NOVEL ANTICANCER AGENTS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2006-02-23 | — | — | WO | disclosed |
| US-20050038068-A1 | Thienopyridones as AMPK activators for the treatment of diabetes and obesity | ABBVIE INC. | 2005-02-17 | — | — | US | disclosed |
| US-5670508-A | ANTITUMOR AGENTS FOR BRAIN TUMORS | NATIONAL SCIENCE COUNCIL (TW) | 1997-09-23 | — | — | US | disclosed |
| US-4560690-A | ANTISECRETORY AGENTS, HISTAMINE H2-ANTAGONISTS | PFIZER INC. (US) | 1985-12-24 | — | — | US | disclosed |
| JP-S5661328-A | PURIFICATION OF HALOGENATED PYRUVIC ESTER | SEITETSU KAGAKU CO LTD | 1981-05-26 | — | — | JP | disclosed |