SCHEMBL12986953

SCHEMBL12986953

FC(F)(F)CCNc1cc(Br)cn2ccnc12

nearest known ligand 0.47

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.47
HTR2C P28335 2/20 0.32
HTR2A P28223 1/20 0.32
TTK P33981 2/20 0.31
HDAC6 Q9UBN7 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12986690 0.78 L3MBTL1 (0.50) L3MBTL1HDAC6
SCHEMBL12986658 0.78 L3MBTL1 (0.49) L3MBTL1HTR2CHTR2AHDAC6
SCHEMBL12986160 0.77 TTK (0.41) TTK
SCHEMBL457296 0.76 TRPM5 (0.32) TTK
SCHEMBL13192519 0.74 TTK (0.33) TTK
SCHEMBL7354198 0.73 L3MBTL1 (0.62) L3MBTL1HTR2CHTR2AHDAC6
SCHEMBL14382231 0.73 L3MBTL1 (0.57) L3MBTL1HTR2CHTR2AHDAC6
SCHEMBL14006673 0.73 L3MBTL1 (0.47) L3MBTL1
SCHEMBL13526947 0.73 L3MBTL1 (0.57) L3MBTL1HTR2CHTR2A
SCHEMBL13193052 0.72 TTK (0.46) TTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2694500-B1 SUBSTITUTED IMIDAZOPYRIDINES AND INTERMEDIATES THEREOF Bayer Pharma AG (DE) 2015-05-27 EP disclosed
EP-2694500-B1 SUBSTITUTED IMIDAZOPYRIDINES AND INTERMEDIATES THEREOF Bayer Pharma AG (DE) 2015-05-27 EP disclosed
US-20140255392-A1 SUBSTITUTED IMIDAZOPYRIDINES AND INTERMEDIATES THEREOF BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-09-11 US disclosed
US-20140255392-A1 SUBSTITUTED IMIDAZOPYRIDINES AND INTERMEDIATES THEREOF BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-09-11 US disclosed
US-20140255392-A1 SUBSTITUTED IMIDAZOPYRIDINES AND INTERMEDIATES THEREOF BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-09-11 US disclosed
EP-2694500-A1 SUBSTITUTED IMIDAZOPYRIDINES AND INTERMEDIATES THEREOF Bayer Pharma Aktiengesellschaft (DE) 2014-02-12 EP disclosed
WO-2012136531-A1 SUBSTITUTED IMIDAZOPYRIDINES AND INTERMEDIATES THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-10-11 WO disclosed
WO-2012136531-A1 SUBSTITUTED IMIDAZOPYRIDINES AND INTERMEDIATES THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-10-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140255392-A1 SUBSTITUTED IMIDAZOPYRIDINES AND INTERMEDIATES THEREOF FLT4, KDR, VEGFA L3MBTL1 2809/4885HTR2C 2376/4885HTR2A 2602/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.