Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | OGT | O15294 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12945888 | 0.91 | MAPT (0.47) | KIF11TBXAS1PDE3BPDE3APKM | |
| SCHEMBL18713758 | 0.89 | KIF11 (0.57) | KIF11TBXAS1PDE3BPDE3APKM | |
| SCHEMBL18500396 | 0.86 | TBXAS1 (0.54) | KIF11TBXAS1PDE3BPDE3APKM | |
| SCHEMBL19674436 | 0.86 | TBXAS1 (0.54) | KIF11TBXAS1PDE3BPDE3APKM | |
| SCHEMBL2611074 | 0.84 | KIF11 (0.66) | KIF11TBXAS1PDE3BPDE3APKM | |
| SCHEMBL9130044 | 0.84 | TBXAS1 (0.47) | KIF11TBXAS1PDE3BPDE3APKM | |
| SCHEMBL10464330 | 0.84 | KCNH2 (0.50) | KIF11TBXAS1PDE3BPDE3AMAOA | |
| SCHEMBL20801733 | 0.81 | KIF11 (0.52) | KIF11TBXAS1PDE3BPDE3APKM | |
| SCHEMBL22184244 | 0.81 | KIF11 (0.52) | KIF11TBXAS1PDE3BPDE3APKM | |
| SCHEMBL8917088 | 0.81 | KCNH2 (0.53) | KIF11TBXAS1PDE3BPDE3APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846929-B2 | Using 1-(4-((2-(aminopyrimidin-5-yl)-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-(methylsulfonyl)ethanone; lipid kinase inhibitor; anticancer agents ; antiinflammatory agents; antidiabetic agents | GENENTECH, INC. (US) | 2010-12-07 | — | — | US | disclosed |