Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22184244 | 1.00 | KIF11 (0.52) | KIF11KCNH2PDE3BPDE3ATBXAS1 | |
| SCHEMBL2611074 | 0.87 | KIF11 (0.66) | KIF11KCNH2PDE3BPDE3ATBXAS1 | |
| SCHEMBL9148322 | 0.86 | KCNH2 (0.58) | KIF11KCNH2PDE3BPDE3ATBXAS1 | |
| SCHEMBL21983115 | 0.85 | AHR (0.53) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL8917088 | 0.84 | KCNH2 (0.53) | KIF11KCNH2PDE3BPDE3ATBXAS1 | |
| SCHEMBL9485923 | 0.84 | KIF11 (0.52) | KIF11KCNH2PDE3BPDE3ATBXAS1 | |
| Hydrochloric Acid SCHEMBL8917748 | 0.83 | KIF11 (0.51) | KIF11KCNH2PDE3BPDE3ATBXAS1 | |
| SCHEMBL12995265 | 0.81 | KIF11 (0.50) | KIF11KCNH2PDE3BPDE3ATBXAS1 | |
| SCHEMBL11574095 | 0.80 | KIF11 (0.52) | KIF11KCNH2PDE3BPDE3ATBXAS1 | |
| SCHEMBL18500396 | 0.79 | TBXAS1 (0.54) | KIF11KCNH2PDE3BPDE3ATBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190077762-A1 | QUINOLONE COMPOUND | OTSUKA PHARMA CO LTD (JP) | 2019-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190077762-A1 | QUINOLONE COMPOUND | HAX1, NQO2, NHERF1 | KIF11 1498/4885KCNH2 38/4885PDE3B 1731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.