Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.45 |
| ▸ | XDH | P47989 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13004936 | 0.89 | XDH (0.45) | XDHS1PR1S1PR5 | |
| SCHEMBL1331310 | 0.89 | XDH (0.49) | XDHNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL23794763 | 0.85 | HSD17B1 (0.57) | HSD17B1HSD17B2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13140006 | 0.81 | HDAC3 (0.42) | XDHS1PR1S1PR5LRRK2AR | |
| SCHEMBL13004637 | 0.81 | XDH (0.54) | XDHSMN1; SMN2S1PR1S1PR5 | |
| SCHEMBL13118072 | 0.81 | HSD17B1 (0.46) | HSD17B1HSD17B2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3384040 | 0.80 | XDH (0.60) | XDHNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL3385772 | 0.77 | XDH (0.46) | XDHMAPTGRM5 | |
| SCHEMBL23794627 | 0.76 | NPC1 (0.49) | XDHNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL13004937 | 0.76 | XDH (0.45) | HSD17B1HSD17B2XDHARGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1932832-B1 | TRIARYLCARBOXYLIC ACID DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2010-12-01 | — | — | EP | disclosed |
| EP-1932832-A1 | TRIARYLCARBOXYLIC ACID DERIVATIVE | Astellas Pharma Inc. (JP) | 2008-06-18 | — | — | EP | disclosed |