Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | CETP | P11597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13060702 | 0.88 | CALM1 (0.38) | CALM1CAMKK2KDM4EALDH1A1TDP1 | |
| SCHEMBL13005651 | 0.80 | CALM1 (0.36) | CALM1CAMKK2ALDH1A1 | |
| SCHEMBL13005691 | 0.79 | OPRM1 (0.43) | CALM1CAMKK2 | |
| SCHEMBL13005432 | 0.78 | OPRM1 (0.44) | CALM1CAMKK2ALDH1A1 | |
| SCHEMBL13005625 | 0.77 | BCHE (0.47) | CALM1CAMKK2MEN1KMT2ABCHE | |
| SCHEMBL13005440 | 0.76 | CALM1 (0.59) | CALM1CAMKK2KDM4EALDH1A1MEN1 | |
| SCHEMBL13005422 | 0.75 | CALM1 (0.48) | CALM1CAMKK2KDM4EALDH1A1MEN1 | |
| SCHEMBL13005722 | 0.74 | CALM1 (0.48) | CALM1CAMKK2KDM4EALDH1A1TDP1 | |
| SCHEMBL13005681 | 0.74 | CALM1 (0.48) | CALM1CAMKK2KDM4EALDH1A1MEN1 | |
| SCHEMBL13005558 | 0.74 | KDM4E (0.54) | CALM1CAMKK2KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |