Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | UBE2M | P61081 | 1/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13061039 | 0.90 | SMN1; SMN2 (0.52) | NPY5RSMN1; SMN2POLBRAB9AEPHX2 | |
| SCHEMBL13005674 | 0.83 | SMN1; SMN2 (0.46) | NPY5RSMN1; SMN2ACKR3RAB9AEPHX2 | |
| SCHEMBL13005597 | 0.76 | ALDH1A1 (0.42) | SMN1; SMN2ATMALDH1A1GAAL3MBTL1 | |
| SCHEMBL13005589 | 0.71 | KMT2A (0.41) | ALDH1A1GAAL3MBTL1PSEN1PSEN2 | |
| SCHEMBL13005671 | 0.71 | F2 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13005486 | 0.69 | F2 (0.39) | RENATMALDH1A1GAAL3MBTL1 | |
| SCHEMBL13061126 | 0.69 | NPC1 (0.54) | POLBRAB9AEPHX2EPHX1NPC1 | |
| SCHEMBL13005624 | 0.69 | MAPK1 (0.46) | — | |
| SCHEMBL13005499 | 0.68 | ALDH1A1 (0.36) | RENALDH1A1GAAL3MBTL1PSEN1 | |
| SCHEMBL14752838 | 0.67 | NPSR1 (0.55) | POLBRAB9AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |