Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | F10 | P00742 | 2/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 3/20 | 0.43 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 4/20 | 0.39 |
| ▸ | BACE1 | P56817 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13060826 | 0.90 | CTSL (0.44) | F2F10PRSS1PSEN1PSEN2 | |
| SCHEMBL13005542 | 0.84 | CTSD (0.40) | F2F10PRSS1MEN1KMT2A | |
| SCHEMBL13005434 | 0.84 | HDAC4 (0.45) | F2F10PRSS1CTSLCTSS | |
| SCHEMBL13005436 | 0.84 | HDAC4 (0.45) | F2F10PRSS1CTSLCTSS | |
| SCHEMBL13005665 | 0.83 | MME (0.51) | CTSLCTSSCTSKCTSBHPGDS | |
| SCHEMBL13005538 | 0.82 | CTSS (0.42) | F2F10PRSS1PSEN1PSEN2 | |
| SCHEMBL13005525 | 0.82 | CTSS (0.42) | F2F10PRSS1PSEN1PSEN2 | |
| SCHEMBL13005486 | 0.82 | F2 (0.39) | F2F10PRSS1PSEN1PSEN2 | |
| SCHEMBL13256338 | 0.81 | CTSL (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13005674 | 0.81 | SMN1; SMN2 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |