Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1761371 | 0.81 | PHLPP2 (0.38) | MAOAADRB3CYP3A4MMP2MMP13 | |
| SCHEMBL1761565 | 0.76 | TAS1R3 (0.45) | USP28MMP2MMP13HDAC8MMP1 | |
| SCHEMBL1761427 | 0.74 | GAA (0.54) | CHRM2CHRM3MAOAHTR2CCHRNA4 | |
| SCHEMBL2296905 | 0.73 | SMN1; SMN2 (0.46) | — | |
| SCHEMBL2296907 | 0.73 | SMN1; SMN2 (0.46) | — | |
| SCHEMBL1756304 | 0.72 | HSD17B1 (0.41) | CYP3A4MMP2MMP9ALDH1A1GAA | |
| SCHEMBL23298050 | 0.69 | MAPK1 (0.34) | PDK2PIK3CA | |
| SCHEMBL3620444 | 0.69 | ADAMTS4 (0.58) | MTORMMP2MMP13MMP16ADAM17 | |
| SCHEMBL3613169 | 0.69 | ADAMTS4 (0.58) | MTORMMP2MMP13MMP16ADAM17 | |
| SCHEMBL23298049 | 0.69 | MAPK1 (0.34) | PDK2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805156-B1 | PREPARATION AND USE OF BIPHENYL-4-YL-CARBONYLAMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2010-12-22 | — | — | EP | disclosed |