Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.61 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13007504 | 0.82 | KMT2A (0.68) | TAS1R3TAS1R1NPSR1ALDH1A1KDM4E | |
| SCHEMBL701314 | 0.76 | TAS1R3 (1.00) | TAS1R3TAS1R1NPSR1ALDH1A1KDM4E | |
| SCHEMBL703637 | 0.76 | TAS1R3 (1.00) | TAS1R3TAS1R1NPSR1ALDH1A1KDM4E | |
| SCHEMBL7780152 | 0.75 | HRH3 (0.54) | ALDH1A1KDM4E | |
| SCHEMBL30046159 | 0.73 | HTT (0.68) | TAS1R3TAS1R1NPSR1ALDH1A1HPGD | |
| SCHEMBL30751972 | 0.73 | HTT (0.68) | TAS1R3TAS1R1NPSR1ALDH1A1HPGD | |
| SCHEMBL1441796 | 0.73 | HTT (0.68) | TAS1R3TAS1R1NPSR1ALDH1A1HPGD | |
| SCHEMBL2358933 | 0.73 | HTT (0.68) | TAS1R3TAS1R1NPSR1ALDH1A1HPGD | |
| SCHEMBL31730298 | 0.72 | TAOK3 (0.64) | ALDH1A1HPGD | |
| SCHEMBL5652051 | 0.72 | TAOK3 (0.64) | ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861377-B1 | BENZIMIDAZOLONE DERIVATIVES AS CB2 RECEPTOR LIGANDS | PFIZER (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2008032164-A2 | BENZIMIDAZOLONE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-03-20 | — | — | WO | disclosed |