Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7786896 | 0.83 | DRD2 (0.51) | HRH3DRD2 | |
| SCHEMBL7780082 | 0.80 | ALDH1A1 (0.54) | ALDH1A1KDM4E | |
| SCHEMBL18995758 | 0.79 | ALDH1A1 (0.60) | ALDH1A1KDM4ETSHR | |
| SCHEMBL18995759 | 0.78 | ALDH1A1 (0.55) | ALDH1A1KDM4ETSHR | |
| SCHEMBL62691 | 0.78 | HTT (0.64) | ALDH1A1KDM4ETSHR | |
| SCHEMBL19289840 | 0.78 | HTT (0.64) | ALDH1A1KDM4ETSHR | |
| SCHEMBL62692 | 0.78 | HTT (0.64) | ALDH1A1KDM4ETSHR | |
| SCHEMBL7504819 | 0.77 | HTR2A (0.46) | HRH3SIGMAR1 | |
| SCHEMBL7495770 | 0.77 | HTR2A (0.46) | HRH3SIGMAR1 | |
| SCHEMBL7504825 | 0.77 | HTR2A (0.46) | HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140852-A1 | 1,2,3,4-TETRAHYDRONAPHTHALENES AND THEIR PHARAMACEUTICAL USE | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035882-A1 | 1,2,3,4-TETRAHYDRONAPHTHALENES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2000-06-22 | — | — | WO | disclosed |