Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13012934 | 0.84 | KMT2A (0.34) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL13013572 | 0.80 | KMT2A (0.37) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL13014413 | 0.68 | ALDH1A1 (0.57) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL22093132 | 0.61 | MAT2A (0.57) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL31145399 | 0.61 | MAT2A (0.57) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL22094062 | 0.61 | MAP3K11 (0.45) | LMNAKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5437607 | 0.60 | KDM4E (0.46) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL6314968 | 0.60 | DHFR (0.46) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL3554510 | 0.60 | CSNK2A1 (0.43) | LMNAKMT2AMEN1SMN1; SMN2TP53 | |
| SCHEMBL22103484 | 0.60 | MAP3K11 (0.41) | LMNAKMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010149786-A1 | PYRIDO [2, 3-D] PYRIMIDINES AS WNT ANTAGONISTS FOR TREATMENT OF CANCER AND ARTHRITIS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2010-12-29 | — | — | WO | disclosed |