Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13014019 | 0.95 | ADORA3 (0.43) | MAPTLMNAADORA3ACHEBRD4 | |
| SCHEMBL13014069 | 0.92 | ADORA3 (0.41) | MAPTLMNAADORA3ACHEBRD4 | |
| SCHEMBL13013474 | 0.91 | ADORA3 (0.43) | MAPTADORA3ACHECACNA1FCACNA1D | |
| SCHEMBL13014462 | 0.91 | ADORA3 (0.40) | MAPTLMNAADORA3ACHEBRD4 | |
| SCHEMBL13014018 | 0.91 | ACHE (0.40) | MAPTLMNAADORA3ACHEBRD4 | |
| SCHEMBL13014277 | 0.90 | OPRD1 (0.45) | MAPTLMNAADORA3ACHEBRD4 | |
| SCHEMBL13013581 | 0.90 | MAPT (0.45) | MAPTLMNATP53POLBKDM4E | |
| SCHEMBL13014246 | 0.88 | ADORA3 (0.42) | MAPTADORA3ACHEBRD4BRD2 | |
| SCHEMBL13013471 | 0.88 | ADORA3 (0.41) | MAPTADORA3ACHEBRD4BRD2 | |
| SCHEMBL13014287 | 0.85 | ADORA3 (0.44) | MAPTADORA3ACHECACNA1FCACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010149786-A1 | PYRIDO [2, 3-D] PYRIMIDINES AS WNT ANTAGONISTS FOR TREATMENT OF CANCER AND ARTHRITIS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2010-12-29 | — | — | WO | disclosed |