Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 4/20 | 0.41 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.41 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.41 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433382 | 0.83 | MAPT (0.46) | ALDH1A1MAPTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL3433379 | 0.83 | MAPT (0.46) | ALDH1A1MAPTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL13014213 | 0.75 | MAPT (0.54) | ALDH1A1MAPTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL13014211 | 0.74 | ALDH1A1 (0.53) | ALDH1A1MAPTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL13014413 | 0.74 | ALDH1A1 (0.57) | ALDH1A1MAPTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL9976406 | 0.73 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL13014219 | 0.73 | ALDH1A1 (0.51) | ALDH1A1MAPTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL13014274 | 0.73 | MAPT (0.55) | ALDH1A1MAPTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL13013968 | 0.72 | MAPT (0.48) | ALDH1A1MAPTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL13014223 | 0.72 | ALDH1A1 (0.49) | ALDH1A1MAPTSMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010149786-A1 | PYRIDO [2, 3-D] PYRIMIDINES AS WNT ANTAGONISTS FOR TREATMENT OF CANCER AND ARTHRITIS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2010-12-29 | — | — | WO | disclosed |