Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PDE2A | O00408 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16478395 | 0.96 | MAPT (0.50) | ALDH1A1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL9976397 | 0.96 | MAPT (0.50) | ALDH1A1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL9976402 | 0.95 | ALDH1A1 (0.49) | ALDH1A1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL9976401 | 0.95 | ALDH1A1 (0.48) | ALDH1A1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL9976404 | 0.94 | GAA (0.53) | ALDH1A1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL9976400 | 0.92 | ALDH1A1 (0.54) | ALDH1A1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL9976399 | 0.92 | MAPT (0.47) | ALDH1A1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL9976403 | 0.91 | ALDH1A1 (0.46) | ALDH1A1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL13013899 | 0.91 | ALDH1A1 (0.46) | ALDH1A1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL9976405 | 0.90 | ALDH1A1 (0.47) | ALDH1A1MAPTKDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629272-B2 | Tricyclic pyrimidine derivatives as wnt antagonists | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2014-01-14 | — | — | US | disclosed |
| US-8629272-B2 | Tricyclic pyrimidine derivatives as wnt antagonists | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2014-01-14 | — | — | US | disclosed |
| US-20120157481-A1 | TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS | DEUTSCHES KREBSFORSCHUNGSZENTRUM | 2012-06-21 | — | — | US | disclosed |
| US-20120157481-A1 | TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS | DEUTSCHES KREBSFORSCHUNGSZENTRUM | 2012-06-21 | — | — | US | disclosed |
| EP-2266985-A1 | Tricyclic Pyrimidine Derivatives as Wnt antagonists | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2010-12-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157481-A1 | TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS | WNT1, WNT3, WNT3A | ALDH1A1 1200/4885MAPT 2558/4885KDM4E 3910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.