Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433379 | 1.00 | MAPT (0.46) | MAPTALDH1A1MEN1KMT2APOLB | |
| SCHEMBL13014262 | 0.83 | ALDH1A1 (0.47) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL13013024 | 0.75 | USP2 (0.44) | MAPTALDH1A1MEN1KMT2APOLB | |
| SCHEMBL3434852 | 0.74 | CACNA1B (0.46) | MAPTALDH1A1MEN1KMT2APOLB | |
| SCHEMBL3434850 | 0.74 | CACNA1B (0.46) | MAPTALDH1A1MEN1KMT2APOLB | |
| SCHEMBL13014213 | 0.73 | MAPT (0.54) | MAPTALDH1A1MEN1KMT2APOLB | |
| SCHEMBL13014211 | 0.73 | ALDH1A1 (0.53) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL13013968 | 0.72 | MAPT (0.48) | MAPTALDH1A1MEN1KMT2APOLB | |
| SCHEMBL13014413 | 0.72 | ALDH1A1 (0.57) | MAPTALDH1A1MEN1KMT2APOLB | |
| SCHEMBL9976406 | 0.72 | ALDH1A1 (0.54) | MAPTALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2266984-A1 | Pyrido[2,3-d]pyrimidines as Wnt antagonists for treatment of cancer and arthritis | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2010-12-29 | — | — | EP | disclosed |