Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | GPR3 | P46089 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20611582 | 0.84 | CYP2C19 (0.43) | CYP17A1CYP2C9CYP2C19PPARGPPARD | |
| SCHEMBL19841942 | 0.80 | MAOB (0.64) | PPARG | |
| SCHEMBL8179186 | 0.80 | TAAR1 (0.46) | CYP17A1CYP2C9CYP2C19GPR3ALDH1A1 | |
| SCHEMBL498377 | 0.79 | ALDH1A1 (0.56) | CYP17A1CYP2C9CYP2C19GPR3ALDH1A1 | |
| SCHEMBL10271093 | 0.79 | SMN1; SMN2 (0.45) | CYP17A1CYP2C9CYP2C19PPARAGPR3 | |
| SCHEMBL8289226 | 0.79 | PTGS1 (0.43) | CYP2C9ACACBSLC6A4LMNA | |
| SCHEMBL25443770 | 0.78 | TDP1 (0.48) | ACACBSLC6A4 | |
| SCHEMBL5018838 | 0.77 | CYP17A1 (0.57) | CYP17A1CYP2C9CYP2C19CACNA1GCACNA1H | |
| SCHEMBL1912504 | 0.77 | ACACB (0.51) | PPARGPPARAACACBALDH1A1SLC6A4 | |
| SCHEMBL13719230 | 0.76 | ALDH1A1 (0.46) | PPARGPPARAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154291-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |
| US-10836740-B2 | Antifungal compound process | Mycovia Pharmaceuticals, Inc. (US) | 2020-11-17 | — | — | US | disclosed |
| US-8471024-B2 | Tetrahydrofuropyridones | MERCK SHARP & DOHME, CORP. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20100331358-A1 | TETRAHYDROFUROPYRIDONES | MERCK SHARP & DOHME LLC | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331358-A1 | TETRAHYDROFUROPYRIDONES | HIF1AN, EGLN3, HIF1A | CYP17A1 1096/4885CYP2C9 2399/4885CYP2C19 1336/4885 |
| US-10836740-B2 | Antifungal compound process | ERG28, CYP51A1, DPM1 | CYP17A1 162/4885CYP2C9 114/4885CYP2C19 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.