Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 16/20 | 0.43 |
| ▸ | FEN1 | P39748 | 17/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15060590 | 0.83 | ALOX5AP (0.45) | ALOX5APFEN1GRM5 | |
| SCHEMBL13017141 | 0.79 | GRM2 (0.45) | ALOX5APFEN1 | |
| SCHEMBL13017166 | 0.75 | CYP11B1 (0.39) | ALOX5APFEN1 | |
| SCHEMBL6466753 | 0.71 | NOS3 (0.40) | — | |
| SCHEMBL5531880 | 0.70 | ESR1 (0.41) | — | |
| SCHEMBL19248543 | 0.70 | KMO (0.47) | ALOX5APFEN1 | |
| SCHEMBL30540118 | 0.70 | KMO (0.47) | ALOX5APFEN1 | |
| SCHEMBL13017168 | 0.70 | CYP1A2 (0.42) | ALOX5APFEN1 | |
| SCHEMBL25071922 | 0.70 | KCNH2 (0.41) | ALOX5APFEN1GRM5 | |
| SCHEMBL13017170 | 0.70 | ALOX5AP (0.48) | ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8471024-B2 | Tetrahydrofuropyridones | MERCK SHARP & DOHME, CORP. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20100331358-A1 | TETRAHYDROFUROPYRIDONES | MERCK SHARP & DOHME LLC | 2010-12-30 | — | — | US | disclosed |
| US-20100331358-A1 | TETRAHYDROFUROPYRIDONES | MERCK SHARP & DOHME LLC | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331358-A1 | TETRAHYDROFUROPYRIDONES | HIF1AN, EGLN3, HIF1A | ALOX5AP 1075/4885FEN1 4018/4885GRM5 1743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.