Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 4/20 | 0.48 |
| ▸ | FEN1 | P39748 | 4/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15060594 | 0.85 | ALOX5AP (0.48) | ALOX5APFEN1GPR84RORCSCN9A | |
| SCHEMBL13017150 | 0.82 | RORC (0.49) | ALOX5APFEN1GPR84RORCSCN9A | |
| SCHEMBL13017168 | 0.75 | CYP1A2 (0.42) | ALOX5APFEN1 | |
| SCHEMBL266175 | 0.71 | RORC (0.54) | ALOX5APFEN1GPR84RORCSCN9A | |
| SCHEMBL13017164 | 0.70 | ALOX5AP (0.43) | ALOX5APFEN1 | |
| SCHEMBL14744175 | 0.69 | ALOX5AP (0.51) | ALOX5APFEN1GPR84RORCSCN9A | |
| SCHEMBL2662469 | 0.69 | SLC6A2 (0.49) | — | |
| SCHEMBL13017143 | 0.68 | ALOX5AP (0.45) | ALOX5APFEN1RORCSCN9A | |
| SCHEMBL27955785 | 0.67 | HSD11B1 (0.50) | ALOX5APFEN1SCN9AHSD11B1PDE10A | |
| SCHEMBL8230055 | 0.67 | GRM5 (0.52) | ALOX5APFEN1GPR84SCN9AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8471024-B2 | Tetrahydrofuropyridones | MERCK SHARP & DOHME, CORP. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20100331358-A1 | TETRAHYDROFUROPYRIDONES | MERCK SHARP & DOHME LLC | 2010-12-30 | — | — | US | disclosed |
| US-20100331358-A1 | TETRAHYDROFUROPYRIDONES | MERCK SHARP & DOHME LLC | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331358-A1 | TETRAHYDROFUROPYRIDONES | HIF1AN, EGLN3, HIF1A | ALOX5AP 1075/4885FEN1 4018/4885GPR84 1736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.