Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.60 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.39 |
| ▸ | OGA | O60502 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13018736 | 0.76 | HRH3 (0.70) | HRH3HRH4ROCK1OGAMAP3K14 | |
| SCHEMBL2166795 | 0.75 | HRH3 (1.00) | HRH3HRH4ROCK1OGAROCK2 | |
| SCHEMBL13018665 | 0.75 | HRH3 (0.65) | HRH3HRH4ROCK1ALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL3786113 | 0.74 | HRH3 (0.97) | HRH3HRH4ROCK1OGAROCK2 | |
| SCHEMBL13018670 | 0.74 | HRH3 (0.76) | HRH3HRH4ROCK1ROCK2ALDH1A1 | |
| SCHEMBL27454974 | 0.73 | HRH3 (0.66) | HRH3HRH4ROCK1OGAROCK2 | |
| SCHEMBL30954035 | 0.73 | HRH3 (0.66) | HRH3HRH4ROCK1OGAROCK2 | |
| SCHEMBL18072491 | 0.71 | HRH3 (0.62) | HRH3HRH4ROCK1OGAROCK2 | |
| SCHEMBL17626748 | 0.70 | HRH3 (0.71) | HRH3HRH4ROCK1OGAMAP3K14 | |
| SCHEMBL14880196 | 0.70 | HRH3 (0.71) | HRH3HRH4ROCK1OGAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | HRH2, HRH4, HRH3 | HRH3 3/4885HRH4 2/4885ROCK1 4266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.