Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 3/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13018743 | 1.00 | ATM (0.33) | ATMACEREN | |
| SCHEMBL26252917 | 0.79 | MMP2 (0.38) | — | |
| SCHEMBL25728480 | 0.78 | CCR2 (0.38) | ATMACEREN | |
| SCHEMBL799809 | 0.78 | CCR2 (0.38) | ATMACEREN | |
| SCHEMBL10125636 | 0.78 | CCR2 (0.38) | ATMACEREN | |
| SCHEMBL25896568 | 0.77 | — | — | |
| SCHEMBL7346021 | 0.77 | — | — | |
| SCHEMBL12765090 | 0.77 | — | — | |
| SCHEMBL27617063 | 0.75 | AGTR2 (0.36) | ATMACEREN | |
| SCHEMBL15451884 | 0.73 | CYP1A2 (0.45) | ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2261234-A2 | Inhibitors of caspases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-15 | — | — | EP | disclosed |