Zebularine

Zebularine

SCHEMBL13032

O=c1ncccn1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CDA P32320 2/20 1.00
▸ MAPT P10636 2/20 1.00
▸ LMNA P02545 2/20 0.61
▸ MTOR P42345 2/20 0.61
▸ THRB P10828 1/20 0.61
▸ MDM2 Q00987 1/20 0.61
▸ NCOA1 Q15788 1/20 0.61
▸ NCOA3 Q9Y6Q9 1/20 0.61
▸ ALDH1A1 P00352 2/20 0.58
▸ TP53 P04637 2/20 0.58
▸ HTT P42858 2/20 0.58
▸ BLM P54132 2/20 0.58
▸ GMNN O75496 1/20 0.58
▸ NFKB1 P19838 1/20 0.58
▸ DNMT1 P26358 1/20 0.58
▸ THPO P40225 1/20 0.58
▸ RAB9A P51151 1/20 0.58
▸ HBB P68871 1/20 0.58
▸ PMP22 Q01453 1/20 0.58
▸ SLC28A1 O00337 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Zebularine SCHEMBL12040244 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL12595413 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL7122633 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL11910465 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL2563757 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL1649826 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL19656926 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL21842491 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL21474114 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL1444853 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7297 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2026-05-28 — — US claimed
CN-122070932-A Application of combination of decitabine and anti-HER 2 antibody in preparation of medicines for treating tumors 上海交通大学 2026-05-22 — — CN claimed
US-20260139030-A1 CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION SHATTUCK LABS INC (US) 2026-05-21 — — US claimed
EP-4729064-A1 DE-DIFFERENTIATED FIBROBLAST-CONDITIONED MEDIA FOR TREATING OR PREVENTING DISC DEGENERATION FibroBiologics, Inc. (US) 2026-04-22 — — EP claimed
EP-3787647-B1 DE-DIFFERENTIATED FIBROBLAST-CONDITIONED MEDIA FOR TREATING OR PREVENTING DISC DEGENERATION FIBROBIOLOGICS INC (US) 2026-04-15 — — EP claimed
EP-4705481-A2 CIRCULAR RNA COMPOSITIONS AND METHODS Orna Therapeutics, Inc. (US) 2026-03-11 — — EP claimed
EP-4695235-A1 NOVEL GSPT1 DEGRADER AND USE THEREOF Cyrus Therapeutics Inc. (KR) 2026-02-18 — — EP claimed
EP-4689082-A1 COMPOSITIONS AND METHODS FOR THE TARGETING OF PCSK9 Scribe Therapeutics Inc. (US) 2026-02-11 — — EP claimed
US-12496357-B2 Compositions and methods for treating sickle cell disease YALE UNIVERSITY (US) 2025-12-16 — — US claimed
US-20250345406-A1 CHIMERIC PROTEINS IN AUTOIMMUNITY SHATTUCK LABS INC (US) 2025-11-13 — — US claimed
US-6933287-B1 Dramatic simplification of a method to treat neoplastic disease by radiation GREER SHELDON B (US) 2005-08-23 — — US claimed
US-20050119201-A1 Inhibitor of dna methylation UNIVERSITY OF MIAMI 2005-06-02 — — US claimed
US-20040192639-A1 Dramatic simplification of a method to treat neoplastic disease by radiation GREER SHELDON B (US) 2004-09-30 — — US claimed
EP-1418949-A2 INHIBITOR OF DNA METHYLATION THE STATE OF OREGON acting by and through THE STATE BOARD OF HIGHER EDUCATION on behalf of THE UNIVERSITY OF OREGON (US) 2004-05-19 — — EP claimed
EP-1315736-A2 NUCLEOSIDE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C F. HOFFMANN-LA ROCHE AG (CH) 2003-06-04 — — EP claimed
WO-2003012051-A2 INHIBITOR OF DNA METHYLATION THE STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON (US) 2003-02-13 — — WO claimed
WO-2002018404-A2 NUCLEOSIDE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C F. HOFFMANN-LA ROCHE AG (CH) 2002-03-07 — — WO claimed
EP-1156827-A2 TREATMENT OF NEOPLASTIC DISEASES BY RADIATION Halogenetics, Inc. (US) 2001-11-28 — — EP claimed
WO-2000051639-A9 TREATMENT OF NEOPLASTIC DISEASES BY RADIATION HALOGENETICS INC (US) 2001-10-25 — — WO claimed
WO-2000051639-A2 TREATMENT OF NEOPLASTIC DISEASES BY RADIATION HALOGENETICS, INC. (US) 2000-09-08 — — WO claimed
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