Zebularine

Zebularine

SCHEMBL2563757

O=c1ncccn1C1O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CDA P32320 2/20 1.00
▸ MAPT P10636 2/20 1.00
▸ LMNA P02545 2/20 0.61
▸ MTOR P42345 2/20 0.61
▸ THRB P10828 1/20 0.61
▸ MDM2 Q00987 1/20 0.61
▸ NCOA1 Q15788 1/20 0.61
▸ NCOA3 Q9Y6Q9 1/20 0.61
▸ ALDH1A1 P00352 2/20 0.58
▸ TP53 P04637 2/20 0.58
▸ HTT P42858 2/20 0.58
▸ BLM P54132 2/20 0.58
▸ GMNN O75496 1/20 0.58
▸ NFKB1 P19838 1/20 0.58
▸ DNMT1 P26358 1/20 0.58
▸ THPO P40225 1/20 0.58
▸ RAB9A P51151 1/20 0.58
▸ HBB P68871 1/20 0.58
▸ PMP22 Q01453 1/20 0.58
▸ SLC28A1 O00337 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Zebularine SCHEMBL12040244 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL12595413 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL13032 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL7122633 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL11910465 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL1649826 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL19656926 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL21842491 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL21474114 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB
Zebularine SCHEMBL1444853 1.00 CDA (1.00) CDAMAPTLMNAMTORTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4171552-A1 USE OF A DHODH INHIBITOR COMPOUND IN COMBINATION CANCER THERAPY Les Laboratoires Servier (FR) 2023-05-03 — — EP claimed
WO-2021262881-A1 USE OF A DHODH INHIBITOR COMPOUND IN COMBINATION CANCER THERAPY SERVIER PHARMACEUTICALS, LLC (US) 2021-12-30 — — WO claimed
WO-2015185611-A1 COMPOUNDS AND METHODS FOR INCREASING THE IMMUNE RESPONSE TO PAPILLOMAVIRUS UNIVERSITÄTSKLINIKUM HEIDELBERG (DE) 2015-12-10 — — WO claimed
EP-2952182-A1 Compounds and methods for increasing the immune response to papillomavirus Universitätsklinikum Heidelberg (DE) 2015-12-09 — — EP claimed
WO-2023237710-A1 CANCER TREATMENT BY ARSENIC TRIOXIDE COMBINATION THERAPY Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 2023-12-14 — — WO disclosed
WO-2020231937-A1 IRF2 AS A PROGNOSTIC BIOMARKER AND TARGET FOR AUGMENTING IMMUNOTHERAPY UNIVERSITY OF MASSACHUSETTS (US) 2020-11-19 — — WO disclosed
EP-3509570-A1 TABLET COMPOSITIONS Celgene Corporation (US) 2019-07-17 — — EP disclosed
WO-2018048847-A1 TABLET COMPOSITIONS CELGENE CORPORATION (US) 2018-03-15 — — WO disclosed
WO-2017035453-A1 COMPOSITIONS AND METHODS FOR TREATING SOLID TUMORS THE JOHNS HOPKINS UNIVERSITY (US) 2017-03-02 — — WO disclosed
WO-2015185611-A1 COMPOUNDS AND METHODS FOR INCREASING THE IMMUNE RESPONSE TO PAPILLOMAVIRUS UNIVERSITÄTSKLINIKUM HEIDELBERG (DE) 2015-12-10 — — WO disclosed
EP-2952182-A1 Compounds and methods for increasing the immune response to papillomavirus Universitätsklinikum Heidelberg (DE) 2015-12-09 — — EP disclosed
WO-2015139013-A1 FUNCTIONAL SCAFFOLD FOR TISSUE REPAIR AND REGENERATION HAN BO (US) 2015-09-17 — — WO disclosed
US-6280936-B1 USEFUL FOR CLEAVAGE OF RIBONUCLEIC ACID (RNA) AND DEOXYRIBONUCLEIC ACID RIBOZYME PHARMACEUTICALS, INC. 2001-08-28 — — US disclosed
EP-1098969-A2 USE OF NUCLEIC ACID MOLECULES AS ANTIVIRAL AGENTS RIBOZYME PHARMACEUTICALS, INC. (US) 2001-05-16 — — EP disclosed
EP-0980424-A2 ENZYMATIC NUCLEIC ACIDS: SYNTHESIS, SELECTION AND USE RIBOZYME PHARMACEUTICALS, INC. (US) 2000-02-23 — — EP disclosed
WO-2000004141-A2 USE OF NUCLEIC ACID MOLECULES AS ANTIVIRAL AGENTS RIBOZYME PHARMACEUTICALS, INC. (US) 2000-01-27 — — WO disclosed
WO-1998050530-A9 ENZYMATIC NUCLEIC ACIDS: SYNTHESIS, SELECTION AND USE RIBOZYME PHARM INC (US) 1999-03-25 — — WO disclosed
WO-1998050530-A2 ENZYMATIC NUCLEIC ACIDS: SYNTHESIS, SELECTION AND USE RIBOZYME PHARMACEUTICALS, INC. (US) 1998-11-12 — — WO disclosed
WO-1995024185-A1 NOVEL PYRIMIDINE NUCLEOSIDES ISIS PHARMACEUTICALS, INC. (US) 1995-09-14 — — WO disclosed
US-4990499-A Treatment of infections and neoplasms UNIVERSITY OF SASKATCHEWAN (CA) 1991-02-05 — — US disclosed
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