SCHEMBL13033140

SCHEMBL13033140

Cc1cccc(OCC(O)CN2CC(C)OC(C)C2)c1

nearest known ligand 0.76

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 4/20 0.65
KMT2A Q03164 3/20 0.65
ALDH1A1 P00352 3/20 0.62
GAA P10253 2/20 0.62
TSHR P16473 2/20 0.62
MAPK1 P28482 2/20 0.62
MEN1 O00255 2/20 0.60
MAPT P10636 1/20 0.60
SMN1; SMN2 Q16637 4/20 0.56
KDM4E B2RXH2 2/20 0.55
POLB P06746 1/20 0.55
HPGD P15428 1/20 0.55
ACE2 Q9BYF1 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13033214 0.87 USP2 (0.69) L3MBTL1KMT2AALDH1A1GAATSHR
SCHEMBL13033173 0.86 MAPK1 (0.78) L3MBTL1KMT2AALDH1A1GAATSHR
SCHEMBL13033200 0.85 L3MBTL1 (0.61) L3MBTL1KMT2AALDH1A1GAATSHR
SCHEMBL13033218 0.84 L3MBTL1 (0.60) L3MBTL1KMT2AALDH1A1GAATSHR
SCHEMBL20553614 0.81 SMN1; SMN2 (0.81) L3MBTL1KMT2AALDH1A1GAATSHR
SCHEMBL30002240 0.81 SMN1; SMN2 (0.81) L3MBTL1KMT2AALDH1A1GAATSHR
SCHEMBL30416315 0.80 L3MBTL1 (0.97) L3MBTL1KMT2AGAATSHRMAPK1
SCHEMBL16371035 0.80 L3MBTL1 (0.97) L3MBTL1KMT2AGAATSHRMAPK1
SCHEMBL21202616 0.80 L3MBTL1 (0.79) L3MBTL1KMT2AALDH1A1GAATSHR
SCHEMBL21792720 0.80 ACE2 (0.82) L3MBTL1KMT2AALDH1A1GAATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11661580-B2 Method of inhibiting tau phosphorylation CASSAVA SCIENCES, INC. (US) 2023-05-30 US disclosed
US-11661580-B2 Method of inhibiting tau phosphorylation CASSAVA SCIENCES, INC. (US) 2023-05-30 US disclosed
US-11385221-B2 Alzheimer's disease assay in a living patient PAIN THERAPEUTICS, INC. (US) 2022-07-12 US disclosed
US-20210389298-A1 Alzheimer's Disease Assay in a Living Patient PAIN THERAPEUTICS, INC. (US) 2021-12-16 US disclosed
US-20210095248-A1 METHOD OF INHIBITING TAU PHOSPHORYLATION PAIN THERAPEUTICS, INC. 2021-04-01 US disclosed
EP-3791875-A1 METHOD FOR INHIBITING GROWTH OF CANCER CELLS Pain Therapeutics, Inc. (US) 2021-03-17 EP disclosed
US-10760052-B2 Method of inhibiting tau phosphorylation Cassava Science, Inc. (US) 2020-09-01 US disclosed
US-20190271686-A1 ALZHEIMER'S DISEASE ASSAY IN A LIVING PATIENT PAIN THERAPEUTICS, INC. 2019-09-05 US disclosed
US-10363239-B2 Method for inhibiting growth of cancer cells PAIN THERAPEUTICS (US) 2019-07-30 US disclosed
US-20190136184-A1 METHOD OF INHIBITING TAU PHOSPHORYLATION CASSAVA SCIENCES, INC. 2019-05-09 US disclosed
US-20140018341-A1 METHOD OF INHIBITING TAU PHOSPHORYLATION CASSAVA SCIENCES, INC. 2014-01-16 US disclosed
US-20140017698-A1 ALZHEIMER'S DISEASE ASSAY IN A LIVING PATIENT WANG HOAU-YAN (US) 2014-01-16 US disclosed
WO-2014011917-A2 A METHOD OF INHIBITING TAU PHOSPHORYLATION PAIN THERAPEUTICS, INC. (US) 2014-01-16 WO disclosed
US-20140017698-A1 ALZHEIMER'S DISEASE ASSAY IN A LIVING PATIENT WANG HOAU-YAN (US) 2014-01-16 US disclosed
WO-2014012054-A1 ALZHEIMER'S DISEASE ASSAY IN A LIVING PATENT PAIN THERAPEUTICS, INC. (US) 2014-01-16 WO disclosed
US-20140018341-A1 METHOD OF INHIBITING TAU PHOSPHORYLATION CASSAVA SCIENCES, INC. 2014-01-16 US disclosed
US-20100279997-A1 ANALGESIC THAT BINDS FILAMIN A PAIN THERAPEUTICS 2010-11-04 US disclosed
US-20100279996-A1 NOVEL ANALGESIC THAT BINDS FILAMIN A BARBIER LINDSAY BURNS 2010-11-04 US disclosed
US-20100279996-A1 NOVEL ANALGESIC THAT BINDS FILAMIN A BARBIER LINDSAY BURNS 2010-11-04 US disclosed
WO-2010051374-A1 ANALGESIC THAT BINDS FILAMIN A PAIN THERAPEUTICS, INC. (US) 2010-05-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10363239-B2 Method for inhibiting growth of cancer cells FLNA, FLNB, FSCN1 L3MBTL1 1041/4885KMT2A 1666/4885ALDH1A1 3552/4885
US-20190136184-A1 METHOD OF INHIBITING TAU PHOSPHORYLATION FLNA, FLNB, MAPT L3MBTL1 1789/4885KMT2A 1560/4885ALDH1A1 4388/4885
US-10760052-B2 Method of inhibiting tau phosphorylation FLNA, FLNB, MAPT L3MBTL1 1789/4885KMT2A 1560/4885ALDH1A1 4388/4885
US-20100279996-A1 NOVEL ANALGESIC THAT BINDS FILAMIN A FLNA, OPRL1, FLNB L3MBTL1 2524/4885KMT2A 3513/4885ALDH1A1 1291/4885
US-20140018341-A1 METHOD OF INHIBITING TAU PHOSPHORYLATION FLNA, FLNB, MAPT L3MBTL1 1789/4885KMT2A 1560/4885ALDH1A1 4388/4885
US-20210095248-A1 METHOD OF INHIBITING TAU PHOSPHORYLATION FLNA, FLNB, MAPT L3MBTL1 1789/4885KMT2A 1560/4885ALDH1A1 4388/4885
US-11661580-B2 Method of inhibiting tau phosphorylation FLNA, FLNB, MAPT L3MBTL1 1789/4885KMT2A 1560/4885ALDH1A1 4388/4885
US-20100279997-A1 ANALGESIC THAT BINDS FILAMIN A FLNA, FLNB, OPRL1 L3MBTL1 1166/4885KMT2A 3459/4885ALDH1A1 1476/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.