Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | ALDH5A1 | P51649 | 3/20 | 0.44 |
| ▸ | ABAT | P80404 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.44 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.41 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6744755 | 0.98 | KDM4E (0.52) | KDM4EPTGS2RAB9AHSP90AA1NUDT1 | |
| SCHEMBL28475060 | 0.96 | HSP90AA1 (0.54) | KDM4EPTGS2RAB9AHSP90AA1NUDT1 | |
| SCHEMBL8250780 | 0.94 | KDM4E (0.55) | KDM4EPTGS2RAB9AHSP90AA1NUDT1 | |
| SCHEMBL1823144 | 0.81 | NUDT1 (0.53) | KDM4ERAB9AHSP90AA1NUDT1BACE1 | |
| SCHEMBL1823142 | 0.81 | NUDT1 (0.53) | KDM4ERAB9AHSP90AA1NUDT1BACE1 | |
| SCHEMBL23776852 | 0.80 | KDM4E (0.58) | KDM4EPTGS2HSP90AA1BACE1ALDH1A1 | |
| SCHEMBL6620084 | 0.80 | HSP90AA1 (0.46) | KDM4EPTGS2RAB9AHSP90AA1NUDT1 | |
| SCHEMBL28560654 | 0.79 | NUDT1 (0.50) | KDM4EHSP90AA1NUDT1BACE1ALDH1A1 | |
| SCHEMBL5665278 | 0.77 | KDM4E (0.44) | KDM4EPTGS2RAB9AHSP90AA1NUDT1 | |
| SCHEMBL20183968 | 0.76 | ALDH1A1 (0.36) | KDM4EPTGS2RAB9AHSP90AA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2266968-A2 | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors | GENZYME CORPORATION (US) | 2010-12-29 | — | — | EP | disclosed |