SCHEMBL13041500

SCHEMBL13041500

CCc1sc(-c2ccc(Br)cc2C)nc1C1C(=O)C(C)(C)OC(C)(C)C1=O

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ GLA P06280 7/20 0.38
▸ TDP1 Q9NUW8 1/20 0.33
▸ POLB P06746 1/20 0.33
▸ CRHR1 P34998 1/20 0.31
▸ MEN1 O00255 1/20 0.30
▸ PRNP P04156 1/20 0.30
▸ TP53 P04637 1/20 0.30
▸ KMT2A Q03164 1/20 0.30
▸ SMN1; SMN2 Q16637 1/20 0.30
▸ RXFP1 Q9HBX9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13041493 0.88 GLA (0.32) GLATDP1POLB
SCHEMBL13041511 0.87 GLA (0.36) GLATDP1CRHR1MEN1KMT2A
SCHEMBL13078143 0.87 GLA (0.36) GLATDP1
SCHEMBL13041501 0.87 POLB (0.35) GLAPOLBMEN1KMT2A
SCHEMBL13041483 0.83 PTGDR2 (0.37) GLATDP1POLBTP53SMN1; SMN2
SCHEMBL13041555 0.80 GRM2 (0.34) —
SCHEMBL13041491 0.80 KDM4E (0.40) CRHR1KMT2ARXFP1
SCHEMBL13041515 0.80 ADAMTS5 (0.31) —
SCHEMBL10237982 0.79 GLA (0.36) GLATDP1POLBCRHR1TP53
SCHEMBL13058433 0.78 GLA (0.37) GLATDP1CRHR1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8956999-B2 Herbicides SYNGENTA LIMITED (GB) 2015-02-17 — — US disclosed
US-8956999-B2 Herbicides SYNGENTA LIMITED (GB) 2015-02-17 — — US disclosed
EP-2173727-B1 NOVEL HERBICIDES SYNGENTA LTD (GB) 2013-11-06 — — EP disclosed
US-20100279868-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION, INC. (US) 2010-11-04 — — US disclosed
WO-2009000533-A1 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2008-12-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100279868-A1 NOVEL HERBICIDES DDT, HPD, HSD17B1 GLA 3973/4885TDP1 2119/4885POLB 4580/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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