Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MGAM | O43451 | 2/20 | 0.42 |
| ▸ | SI | P14410 | 2/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL836471 | 0.75 | MAPT (0.52) | SIRT2SIRT1MAPTTP53THRB | |
| SCHEMBL4237258 | 0.73 | ALDH1A1 (0.56) | TP53GAAALDH1A1POLBKMT2A | |
| SCHEMBL1925658 | 0.73 | GAA (0.50) | SIRT2MAPTTP53GAAMGAM | |
| SCHEMBL17610628 | 0.72 | KMT2A (0.54) | MAPTTP53ALDH1A1KDM4EPOLB | |
| SCHEMBL28759307 | 0.70 | TP53 (0.65) | MAPTTP53THRBSMN1; SMN2HSD17B10 | |
| SCHEMBL29074193 | 0.69 | GAA (0.50) | SIRT2SIRT1MAPTTP53GAA | |
| SCHEMBL17183509 | 0.69 | MGAM (0.54) | SIRT2SIRT1MAPTTP53THRB | |
| SCHEMBL8934769 | 0.69 | SIRT2 (0.46) | SIRT2SIRT1MAPTTP53THRB | |
| SCHEMBL17610635 | 0.67 | POLB (0.53) | MAPTTP53ALDH1A1KDM4EPOLB | |
| SCHEMBL19197992 | 0.65 | MAPT (0.50) | SIRT2SIRT1MAPTTP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2260846-A1 | Novel methods for the treatment of cancer | Lankenau Institute for Medical Research (US) | 2010-12-15 | — | — | EP | disclosed |
| US-7714139-B2 | IDO inhibitors and methods of use | LANKENAU INSTITUTE FOR MEDCIAL RESEARCH (US) | 2010-05-11 | — | — | US | disclosed |