Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.52 |
| ▸ | TLK2 | Q86UE8 | 4/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1304351 | 1.00 | PIM1 (0.52) | PIM1TLK2PDPK1JAK3PTPN1 | |
| SCHEMBL3130082 | 0.99 | PIM1 (0.52) | PIM1TLK2PDPK1JAK3PTPN1 | |
| SCHEMBL3130088 | 0.99 | PIM1 (0.52) | PIM1TLK2PDPK1JAK3PTPN1 | |
| SCHEMBL1304861 | 0.93 | PIM1 (0.52) | PIM1TLK2PDPK1JAK3PTPN1 | |
| SCHEMBL1304858 | 0.93 | PIM1 (0.52) | PIM1TLK2PDPK1JAK3PTPN1 | |
| SCHEMBL1304433 | 0.92 | PIM1 (0.52) | PIM1TLK2PDPK1JAK3PTPN1 | |
| SCHEMBL1304434 | 0.92 | PIM1 (0.52) | PIM1TLK2PDPK1JAK3PTPN1 | |
| SCHEMBL1304353 | 0.90 | PTPN1 (0.46) | PIM1TLK2PTPN1PTPN2MEN1 | |
| SCHEMBL1304522 | 0.87 | ALDH1A1 (0.58) | PIM1PTPN1PTPN2MEN1KMT2A | |
| SCHEMBL1304521 | 0.87 | ALDH1A1 (0.58) | PIM1PTPN1PTPN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053461-B2 | Oxindole derivative | THERAVALUES CORPORATION (JP) | 2011-11-08 | — | — | US | disclosed |
| US-20100076049-A1 | NOVEL OXINDOLE DERIVATIVE | THERAVALUES CORPORATION (JP) | 2010-03-25 | — | — | US | disclosed |
| EP-2130829-A1 | NOVEL HYDROXYINDOLE DERIVATIVE | Theravalues Corporation (JP) | 2009-12-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076049-A1 | NOVEL OXINDOLE DERIVATIVE | CYP2C9, HDAC10, SIGMAR1 | PIM1 4561/4885TLK2 4211/4885PDPK1 4317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.