Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1304521 | 1.00 | ALDH1A1 (0.58) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL12111075 | 0.88 | ALDH1A1 (0.58) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL3130082 | 0.88 | PIM1 (0.52) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL3130088 | 0.88 | PIM1 (0.52) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL1304434 | 0.88 | PIM1 (0.52) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL1304433 | 0.88 | PIM1 (0.52) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL1304858 | 0.87 | PIM1 (0.52) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL1304861 | 0.87 | PIM1 (0.52) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL1304354 | 0.87 | PIM1 (0.52) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL1304351 | 0.87 | PIM1 (0.52) | ALDH1A1LMNAPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053461-B2 | Oxindole derivative | THERAVALUES CORPORATION (JP) | 2011-11-08 | — | — | US | disclosed |
| US-20100076049-A1 | NOVEL OXINDOLE DERIVATIVE | THERAVALUES CORPORATION (JP) | 2010-03-25 | — | — | US | disclosed |
| EP-2130829-A1 | NOVEL HYDROXYINDOLE DERIVATIVE | Theravalues Corporation (JP) | 2009-12-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076049-A1 | NOVEL OXINDOLE DERIVATIVE | CYP2C9, HDAC10, SIGMAR1 | ALDH1A1 957/4885LMNA 4746/4885POLB 4443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.