Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10989096 | 0.84 | KDM4E (0.68) | NLRP3KDM4ERAD52TLR8TDP1 | |
| SCHEMBL15241845 | 0.83 | KMT2A (0.68) | KDM4ERAD52TDP1KMT2ARAB9A | |
| SCHEMBL12082609 | 0.79 | KMT2A (0.72) | NLRP3KDM4ERAD52TLR8TDP1 | |
| SCHEMBL4728183 | 0.78 | TNF (0.64) | RAB9ALMNASMN1; SMN2HTTNPC1 | |
| SCHEMBL10983849 | 0.77 | TNF (0.71) | NLRP3KDM4ETDP1KMT2ARAB9A | |
| SCHEMBL22860189 | 0.77 | KMT2A (0.49) | NLRP3KDM4ERAD52TLR8TDP1 | |
| SCHEMBL18407705 | 0.77 | CNR2 (0.57) | NLRP3KDM4ERAD52TLR8 | |
| SCHEMBL13459560 | 0.73 | RAB9A (0.48) | NLRP3KDM4ERAD52TLR8TDP1 | |
| SCHEMBL1104855 | 0.73 | RAB9A (0.59) | KDM4EKMT2ARAB9ALMNASMN1; SMN2 | |
| SCHEMBL10980166 | 0.72 | NLRP3 (0.42) | NLRP3KDM4ETLR8KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010137738-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF STRESS-RELATED CONDITIONS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-12-02 | — | — | WO | disclosed |