Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 4/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.65 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.50 |
| ▸ | CTSK | P43235 | 6/20 | 0.48 |
| ▸ | CTSS | P25774 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.41 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9718207 | 0.86 | HDAC4 (0.68) | HDAC4HDAC1HDAC6EPHX1CTSK | |
| SCHEMBL18460227 | 0.86 | HDAC4 (0.68) | HDAC4HDAC1HDAC6EPHX1CTSK | |
| SCHEMBL18460068 | 0.85 | HDAC4 (0.74) | HDAC4HDAC1HDAC6EPHX1CTSK | |
| SCHEMBL1954004 | 0.83 | HDAC4 (0.61) | HDAC4HDAC1HDAC6EPHX1CTSK | |
| SCHEMBL1954006 | 0.83 | HDAC4 (0.61) | HDAC4HDAC1HDAC6EPHX1CTSK | |
| Bicarbonate SCHEMBL3817405 | 0.83 | HDAC4 (0.64) | HDAC4HDAC1HDAC6EPHX1CTSK | |
| SCHEMBL25174673 | 0.81 | HDAC4 (0.58) | HDAC4HDAC1HDAC6EPHX1CTSK | |
| SCHEMBL29244834 | 0.81 | HDAC4 (0.58) | HDAC4HDAC1HDAC6EPHX1CTSK | |
| SCHEMBL5218978 | 0.81 | HDAC4 (0.68) | HDAC4HDAC1HDAC6EPHX1CTSK | |
| SCHEMBL6207008 | 0.81 | HDAC4 (0.68) | HDAC4HDAC1HDAC6EPHX1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010144486-A1 | DIHYDROPYRROLONAPHTYRIDINONE COMPOUNDS AS INHIBITORS OF JAK | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |