Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 4/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.68 |
| ▸ | CTSS | P25774 | 2/20 | 0.58 |
| ▸ | CTSK | P43235 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218978 | 1.00 | HDAC4 (0.68) | HDAC4HDAC1HDAC6CTSSCTSK | |
| SCHEMBL31291788 | 0.96 | HDAC4 (0.63) | HDAC4HDAC1HDAC6CTSSCTSK | |
| SCHEMBL785870 | 0.88 | CTSS (0.56) | HDAC4HDAC1HDAC6CTSSCTSK | |
| SCHEMBL789305 | 0.85 | CTSS (0.56) | HDAC4HDAC1HDAC6CTSSCTSK | |
| SCHEMBL11249810 | 0.84 | LMNA (0.58) | HDAC4HDAC1HDAC6CTSSCTSK | |
| SCHEMBL28740619 | 0.84 | LMNA (0.58) | HDAC4HDAC1HDAC6CTSSCTSK | |
| SCHEMBL7260228 | 0.84 | LMNA (0.58) | HDAC4HDAC1HDAC6CTSSCTSK | |
| SCHEMBL9718207 | 0.83 | HDAC4 (0.68) | HDAC4HDAC1HDAC6CTSSCTSK | |
| SCHEMBL18460227 | 0.83 | HDAC4 (0.68) | HDAC4HDAC1HDAC6CTSSCTSK | |
| SCHEMBL9075549 | 0.83 | HDAC4 (0.49) | HDAC4HDAC1HDAC6CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004050619-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2004-06-17 | — | — | WO | disclosed |