Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | HRH2 | P25021 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | CTSS | P25774 | 6/20 | 0.48 |
| ▸ | CTSK | P43235 | 6/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29244834 | 1.00 | HDAC4 (0.58) | HDAC4HDAC1HDAC6HRH2HRH1 | |
| SCHEMBL9718207 | 0.93 | HDAC4 (0.68) | HDAC4HDAC1HDAC6HRH2HRH1 | |
| SCHEMBL18460227 | 0.93 | HDAC4 (0.68) | HDAC4HDAC1HDAC6HRH2HRH1 | |
| SCHEMBL25761193 | 0.83 | HDAC4 (0.67) | HDAC4HDAC1HDAC6HRH2HRH1 | |
| SCHEMBL13048263 | 0.81 | HDAC4 (0.65) | HDAC4HDAC1HDAC6HRH2HRH1 | |
| SCHEMBL18460068 | 0.80 | HDAC4 (0.74) | HDAC4HDAC1HDAC6HRH2HRH1 | |
| SCHEMBL21285681 | 0.80 | HDAC4 (0.43) | HDAC4HDAC1HDAC6HRH2HRH1 | |
| SCHEMBL4704612 | 0.80 | KMT2A (0.53) | HDAC4HDAC1HDAC6HRH2HRH1 | |
| SCHEMBL12668952 | 0.79 | CTSK (0.49) | CTSSCTSKGAAL3MBTL1CTSL | |
| SCHEMBL14984662 | 0.79 | CTSK (0.49) | CTSSCTSKGAAL3MBTL1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12344614-B2 | Benzodiazepine derivatives as GABA a GAMMA1 PAM | HOFFMANN-LA ROCHE INC. (US) | 2025-07-01 | — | — | US | disclosed |
| CN-118055923-A | Benzodiazepine derivatives as positive allosteric modulators of the GABAA γ1 receptor | 豪夫迈·罗氏有限公司 | 2024-05-17 | — | — | CN | disclosed |
| US-20230142171-A1 | NEW BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | HOFFMANN-LA ROCHE INC. (US) | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12344614-B2 | Benzodiazepine derivatives as GABA a GAMMA1 PAM | GABRA1, GABRB1, GABRA5 | HDAC4 1798/4885HDAC1 1695/4885HDAC6 1196/4885 |
| US-20230142171-A1 | NEW BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | GABRA1, GABRB1, GABRA5 | HDAC4 1740/4885HDAC1 1704/4885HDAC6 1202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.