Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 4/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.68 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | CTSS | P25774 | 3/20 | 0.51 |
| ▸ | CTSK | P43235 | 3/20 | 0.51 |
| ▸ | HRH2 | P25021 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18460227 | 1.00 | HDAC4 (0.68) | HDAC4HDAC1HDAC6EPHX1GAA | |
| SCHEMBL25174673 | 0.93 | HDAC4 (0.58) | HDAC4HDAC1HDAC6EPHX1GAA | |
| SCHEMBL29244834 | 0.93 | HDAC4 (0.58) | HDAC4HDAC1HDAC6EPHX1GAA | |
| SCHEMBL18460068 | 0.88 | HDAC4 (0.74) | HDAC4HDAC1HDAC6EPHX1GAA | |
| SCHEMBL13048263 | 0.86 | HDAC4 (0.65) | HDAC4HDAC1HDAC6EPHX1GAA | |
| Bicarbonate SCHEMBL3817405 | 0.85 | HDAC4 (0.64) | HDAC4HDAC1HDAC6EPHX1GAA | |
| SCHEMBL6207008 | 0.83 | HDAC4 (0.68) | HDAC4HDAC1HDAC6EPHX1GAA | |
| SCHEMBL5218978 | 0.83 | HDAC4 (0.68) | HDAC4HDAC1HDAC6EPHX1GAA | |
| SCHEMBL1954004 | 0.83 | HDAC4 (0.61) | HDAC4HDAC1HDAC6EPHX1GAA | |
| SCHEMBL1954006 | 0.83 | HDAC4 (0.61) | HDAC4HDAC1HDAC6EPHX1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153327-A | 7-Oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease | E. R. SQUIBB & SONS, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| US-5100889-A | Thromboxane A2 receptor antagonists, thromboxane synthetase inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1992-03-31 | — | — | US | disclosed |
| EP-0374952-A2 | 7-Oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease | E.R. SQUIBB & SONS, INC. (US) | 1990-06-27 | — | — | EP | disclosed |