Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12945210 | 0.80 | OPRD1 (0.39) | OPRM1OPRD1OPRK1 | |
| SCHEMBL21859260 | 0.78 | OPRD1 (0.55) | OPRM1OPRD1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL19194810 | 0.77 | OPRM1 (0.51) | OPRM1OPRD1OPRK1 | |
| SCHEMBL19777068 | 0.77 | OPRD1 (0.37) | OPRM1OPRD1OPRK1 | |
| SCHEMBL19198659 | 0.76 | OPRM1 (0.34) | OPRM1OPRD1OPRK1 | |
| SCHEMBL20170829 | 0.76 | OPRD1 (0.46) | OPRM1OPRD1OPRK1 | |
| SCHEMBL21859469 | 0.75 | OPRM1 (0.51) | OPRM1OPRD1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL13257561 | 0.74 | OPRM1 (0.54) | OPRM1OPRD1OPRK1CYP2D6 | |
| SCHEMBL14772785 | 0.74 | OPRM1 (0.54) | OPRM1OPRD1OPRK1CYP2D6 | |
| SCHEMBL13357084 | 0.74 | OPRM1 (0.54) | OPRM1OPRD1OPRK1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010144641-A1 | PREPARATION OF 6-ALPHA-AMINO N-SUBSTITUTED MORPHINANS BY CATALYTIC HYDROGEN TRANSFER | MALLINCKRODT INC. (US) | 2010-12-16 | — | — | WO | disclosed |
| WO-2010039222-A2 | PROCESSES FOR THE SELECTIVE AMINATION OF KETOMORPHINANS | MALLINCKRODT INC. (US) | 2010-04-08 | — | — | WO | disclosed |