Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | RXRB | P28702 | 1/20 | 0.49 |
| ▸ | RXRG | P48443 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13449767 | 0.84 | KDM4E (0.41) | ALDH1A1KDM4EGAAMAPTTDP1 | |
| SCHEMBL19768706 | 0.84 | HSD17B10 (0.49) | CYP1A2CYP2D6CYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL16195513 | 0.81 | ALDH1A1 (0.50) | CYP1A2CYP2D6CYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL6763906 | 0.81 | CYP1A2 (0.53) | CYP1A2CYP2D6CYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL12384894 | 0.80 | CYP1A2 (0.57) | CYP1A2CYP2D6CYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL13253653 | 0.79 | CYP1A2 (0.51) | CYP1A2CYP2D6CYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL19441062 | 0.79 | CYP1A2 (0.51) | CYP1A2CYP2D6CYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL16094351 | 0.79 | CYP1A2 (0.51) | CYP1A2CYP2D6CYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL9515076 | 0.79 | ALDH1A1 (0.55) | CYP1A2CYP2D6CYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL5735923 | 0.79 | CYP1A2 (0.51) | CYP1A2CYP2D6CYP2C19HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298306-A1 | (1,4-Diaza-bicyclo[3.2.2]non-6-en-4-yl)-heterocyclyl-methanone Ligands for Nicotinic Acetylcholine Receptors, Useful for the Treatment of Disease | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-11-25 | — | — | US | disclosed |
| US-20090023728-A1 | 1,2,3,4-Tetrahydroisoquinoline Derivatives, Preparations Thereof and Uses Thereof | ASTRAZENECA AB (SE) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298306-A1 | (1,4-Diaza-bicyclo[3.2.2]non-6-en-4-yl)-heterocyclyl-methanone Ligands for Nicotinic Acetylcholine Receptors, Useful for the Treatment of Disease | CHRNA7, CHRNA6, CHRNA5 | CYP1A2 792/4885CYP2D6 1019/4885CYP2C19 1449/4885 |
| US-20090023728-A1 | 1,2,3,4-Tetrahydroisoquinoline Derivatives, Preparations Thereof and Uses Thereof | OPRD1, QDPR, RECQL | CYP1A2 22/4885CYP2D6 10/4885CYP2C19 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.