Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL301537 | 0.95 | MAPT (0.37) | MAPTCYP2A6ALDH1A1HSD17B10TDP1 | |
| SCHEMBL10323632 | 0.82 | ALDH1A1 (0.44) | MAPTCYP2A6ALDH1A1HSD17B10TDP1 | |
| SCHEMBL29350037 | 0.82 | ALDH1A1 (0.44) | MAPTCYP2A6ALDH1A1HSD17B10TDP1 | |
| SCHEMBL5107 | 0.82 | ALDH1A1 (0.44) | MAPTCYP2A6ALDH1A1HSD17B10TDP1 | |
| SCHEMBL29496111 | 0.82 | ALDH1A1 (0.44) | MAPTCYP2A6ALDH1A1HSD17B10TDP1 | |
| SCHEMBL146878 | 0.82 | ALDH1A1 (0.44) | MAPTCYP2A6ALDH1A1HSD17B10TDP1 | |
| SCHEMBL6932286 | 0.82 | — | — | |
| SCHEMBL7521120 | 0.82 | GPR84 (0.32) | WDR5GPR84 | |
| SCHEMBL5149451 | 0.81 | ALDH1A1 (0.42) | MAPTCYP2A6ALDH1A1HSD17B10TDP1 | |
| Phosphine SCHEMBL8373615 | 0.81 | ALDH1A1 (0.42) | MAPTCYP2A6ALDH1A1HSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552928-B1 | A PROCESS FOR THE REDUCTION OF A TERTIARY PHOSPHINE OXIDE TO THE CORRESPONDING TERTIARY PHOSPHINE IN THE PRESENCE OF A CATALYST AND USE OF A TERTIARY PHOSPHINE FOR REDUCING A TERTIARY PHOSPHINE OXIDE IN THE PRESENCE OF A CATALYST. | CHROMAFORA AB (SE) | 2015-04-15 | — | — | EP | disclosed |
| US-8735629-B2 | Process for the reduction of a tertiary phosphine oxide to the corresponding tertiary phosphine in the presence of a catalyst and use of a tertiary phosphine for reducing a tertiary phosphine oxide in the presence of a catalyst | CHROMAFORA AB (SE) | 2014-05-27 | — | — | US | disclosed |
| US-8426647-B2 | — | — | 2013-04-23 | — | — | US | disclosed |
| US-20130012725-A1 | PROCESS FOR THE REDUCTION OF A TERTIARY PHOSPHINE OXIDE TO THE CORRESPONDING TERTIARY PHOSPHINE IN THE PRESENCE OF A CATALYST AND USE OF A TERTIARY PHOSPHINE FOR REDUCING A TERTIARY PHOSPHINE OXIDE IN THE PRESENCE OF A CATALYST | CHROMAFORA AB (SE) | 2013-01-10 | — | — | US | disclosed |
| US-8053604-B2 | Process for preparation of diphosphine compounds and intermediates for the process | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-08 | — | — | US | disclosed |
| US-8053604-B2 | Process for preparation of diphosphine compounds and intermediates for the process | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-08 | — | — | US | disclosed |
| US-8053604-B2 | Process for preparation of diphosphine compounds and intermediates for the process | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-08 | — | — | US | disclosed |
| US-20100125153-A1 | PROCESS FOR PREPARATION OF DIPHOSPHINE COMPOUNDS AND INTERMEDIATES FOR THE PROCESS | SPERA PHARMA, INC. (JP) | 2010-05-20 | — | — | US | disclosed |
| US-20100125153-A1 | PROCESS FOR PREPARATION OF DIPHOSPHINE COMPOUNDS AND INTERMEDIATES FOR THE PROCESS | SPERA PHARMA, INC. (JP) | 2010-05-20 | — | — | US | disclosed |
| US-20100125153-A1 | PROCESS FOR PREPARATION OF DIPHOSPHINE COMPOUNDS AND INTERMEDIATES FOR THE PROCESS | SPERA PHARMA, INC. (JP) | 2010-05-20 | — | — | US | disclosed |
| EP-0841343-B1 | Ruthenium-optically active phosphine complex, process for the preparation thereof and process for the preparation of optically active 4-methyl-2-oxetanone using same | TAKASAGO PERFUMERY CO LTD (JP) | 2003-02-05 | — | — | EP | disclosed |
| US-6043380-A | FOR ASYMMETRICALLY HYDROGENATING 4-METHYLENE-2-OXETANONE INTO OPTICALLY ACTIVE 4-METHYL-2-OXETANONE | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2000-03-28 | — | — | US | disclosed |
| EP-0955303-A2 | Ruthenium-iodo-optically active phosphine complex | Takasago International Corporation (JP) | 1999-11-10 | — | — | EP | disclosed |
| US-5981782-A | EXHIBITS HIGH CATALYTIC ACTIVITY AND ALLOWS ASYMMETRIC REACTION IN A HIGH ASYMMETRIC YIELD TO OBTAIN A REACTION PRODUCT HAVING A HIGH OPTICAL PURITY | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1999-11-09 | — | — | US | disclosed |
| US-5981771-A | INTERMEDIATE FOR RAW MATERIAL OF POLYMER, SYNTHETIC MATERIAL FOR MEDICINES, LIQUID CRYSTALS; ASYMMETRIC HYDROGENATION OF 4-METHYLENE-2-OXETANONE IN THE PRESENCE OF RUTHENIUM-IODO-OPTICALLY ACTIVE PHOSPHINE CATALYST COMPLEX | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1999-11-09 | — | — | US | disclosed |
| US-5922918-A | Method for making an optically active diphosphine ligand | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1999-07-13 | — | — | US | disclosed |
| EP-0841343-A2 | Ruthenium-optically active phosphine complex, process for the preparation thereof and process for the preparation of optically active 4-methyl-2-oxetanone using same | Takasago International Corporation (JP) | 1998-05-13 | — | — | EP | disclosed |
| EP-0839819-A1 | Method of preparing optically active diphosphine ligands | Takasago International Corporation (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5693868-A | REACTING 2,2'-BIS(TRIFLUOROMETHANESULFONYLOXY)-1,1-BINAPHTHYL WITH A PHOSPHINE OXIDE IN THE PRESENCE OF A TRANSITION METAL-PHOSPHINE COMPLEX | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1997-12-02 | — | — | US | disclosed |
| EP-0771812-A1 | Method for producing an optically active diphosphine | Takasago International Corporation (JP) | 1997-05-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100125153-A1 | PROCESS FOR PREPARATION OF DIPHOSPHINE COMPOUNDS AND INTERMEDIATES FOR THE PROCESS | H1-10, ITPA, RER1 | MAPT 4502/4885CYP2A6 3449/4885ALDH1A1 4580/4885 |
| US-20130012725-A1 | PROCESS FOR THE REDUCTION OF A TERTIARY PHOSPHINE OXIDE TO THE CORRESPONDING TERTIARY PHOSPHINE IN THE PRESENCE OF A CATALYST AND USE OF A TERTIARY PHOSPHINE FOR REDUCING A TERTIARY PHOSPHINE OXIDE IN THE PRESENCE OF A CATALYST | PSPH, PNPO, PHOSPHO1 | MAPT 4143/4885CYP2A6 2442/4885ALDH1A1 2830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.