Sugi Predict

Sugi Predict / Compounds / SCHEMBL1305586

SCHEMBL1305586

SCHEMBL1305586

C=CC[Si](CC=C)(OCC)c1ccc(N(c2ccc(OC)cc2)c2ccc([Si](CC=C)(CC=C)OCC)cc2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.39
▸ TSHR P16473 2/20 0.39
▸ TP53 P04637 2/20 0.39
▸ CYP3A4 P08684 1/20 0.39
▸ ALOX15 P16050 1/20 0.39
▸ ALOX12 P18054 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ HTT P42858 1/20 0.37
▸ KDM4E B2RXH2 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ HSD17B10 Q99714 1/20 0.34
▸ EGFR P00533 2/20 0.33
▸ PDGFRB P09619 2/20 0.33
▸ KDR P35968 2/20 0.33
▸ TUBB4A P04350 1/20 0.33
▸ TUBB P07437 1/20 0.33
▸ TUBA3C P0DPH7 1/20 0.33
▸ TUBA1B P68363 1/20 0.33
▸ TUBA4A P68366 1/20 0.33
▸ TUBB4B P68371 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1306585 0.91 NR1H2 (0.31) —
SCHEMBL4272275 0.88 ALDH1A1 (0.41) ALDH1A1TSHRTP53CYP3A4ALOX15
SCHEMBL1308621 0.85 ALDH1A1 (0.34) ALDH1A1TSHRCYP3A4KDM4EAPP
SCHEMBL6748661 0.77 HTT (0.40) ALDH1A1SMN1; SMN2HTTKDM4ERAB9A
SCHEMBL1305375 0.75 ALDH1A1 (0.38) ALDH1A1TSHR
SCHEMBL1308149 0.75 ESR1 (0.41) ALDH1A1TSHRTP53CYP3A4ALOX15
SCHEMBL1305649 0.75 RELA (0.36) CYP3A4SMN1; SMN2KDM4ERAB9ATUBB4A
SCHEMBL6746664 0.75 HTT (0.39) ALDH1A1SMN1; SMN2HTTKDM4ERAB9A
SCHEMBL6848199 0.75 HTT (0.39) ALDH1A1SMN1; SMN2HTTKDM4ERAB9A
SCHEMBL1306681 0.75 TSHR (0.37) TSHRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8053588-B2 organosilane compounds used as raw materials for synthesis of organosilicon polymer thin films, having a refractive-index controlling function, a light absorbing function, a light emitting function, and a charge transferring function KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 2011-11-08 — — US disclosed
US-8053588-B2 organosilane compounds used as raw materials for synthesis of organosilicon polymer thin films, having a refractive-index controlling function, a light absorbing function, a light emitting function, and a charge transferring function KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 2011-11-08 — — US disclosed
US-20080227939-A1 Organosilane compound and organosilica obtained therefrom KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 2008-09-18 — — US disclosed
US-20080227939-A1 Organosilane compound and organosilica obtained therefrom KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 2008-09-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227939-A1 Organosilane compound and organosilica obtained therefrom CARM1, PRMT1, PRMT8 ALDH1A1 1435/4885TSHR 2852/4885TP53 2923/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.