Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 4/20 | 0.61 |
| ▸ | JAK1 | P23458 | 3/20 | 0.61 |
| ▸ | JAK2 | O60674 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.60 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.60 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9348787 | 0.88 | RAB9A (0.58) | TYK2JAK1JAK2CYP3A4TAS1R3 | |
| SCHEMBL7384072 | 0.83 | TYK2 (0.65) | TYK2JAK1JAK2CYP3A4TAS1R3 | |
| SCHEMBL12092157 | 0.82 | SMO (0.71) | TYK2JAK2KMT2AMAPTRAB9A | |
| SCHEMBL8278654 | 0.81 | TYK2 (0.60) | TYK2JAK1JAK2CYP3A4TAS1R3 | |
| SCHEMBL4154853 | 0.80 | TYK2 (0.71) | TYK2JAK1JAK2CYP3A4TAS1R3 | |
| SCHEMBL14532180 | 0.79 | TYK2 (0.65) | TYK2JAK1JAK2CYP3A4TAS1R3 | |
| SCHEMBL95630 | 0.79 | TYK2 (0.65) | TYK2JAK1JAK2CYP3A4TAS1R3 | |
| SCHEMBL678659 | 0.79 | KMT2A (0.67) | TYK2JAK1JAK2CYP3A4TAS1R3 | |
| SCHEMBL6459176 | 0.78 | NPC1 (0.69) | KMT2AMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16589425 | 0.77 | MAPT (0.77) | KMT2AMAPTRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | UNITED STATES GOVERNMENT | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | FADS2, ACOT7, FADS1 | TYK2 2073/4885JAK1 4237/4885JAK2 4384/4885 |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | FADS2, ACOT7, FADS1 | TYK2 2073/4885JAK1 4237/4885JAK2 4384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.