Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13005558 | 0.87 | KDM4E (0.54) | KDM4EHSD17B10CALM1CAMKK2MEN1 | |
| SCHEMBL172762 | 0.83 | OPRM1 (0.47) | CALM1CAMKK2OPRM1OPRK1OPRD1 | |
| SCHEMBL13061102 | 0.76 | CALM1 (0.64) | KDM4ECALM1CAMKK2MEN1KMT2A | |
| SCHEMBL13060702 | 0.71 | CALM1 (0.38) | KDM4ECALM1CAMKK2MEN1KMT2A | |
| SCHEMBL13061009 | 0.71 | OPRM1 (0.46) | CALM1CAMKK2OPRM1OPRK1OPRD1 | |
| SCHEMBL13061128 | 0.71 | BCHE (0.47) | CALM1CAMKK2MEN1KMT2AOPRM1 | |
| SCHEMBL13005691 | 0.71 | OPRM1 (0.43) | CALM1CAMKK2OPRM1OPRK1OPRD1 | |
| SCHEMBL13061028 | 0.70 | CYP1A2 (0.57) | CALM1CAMKK2MEN1KMT2ABCHE | |
| SCHEMBL13005432 | 0.70 | OPRM1 (0.44) | CALM1CAMKK2OPRM1OPRK1OPRD1 | |
| SCHEMBL13061011 | 0.70 | TAAR1 (0.57) | KDM4ECALM1CAMKK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |