Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.65 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 4/20 | 0.44 |
| ▸ | CETP | P11597 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10039143 | 0.87 | CALM1 (0.64) | CALM1CAMKK2TSHRKDM4EALDH1A1 | |
| SCHEMBL13005707 | 0.83 | CALM1 (0.61) | CALM1CAMKK2TSHRHSD17B10PTGES | |
| SCHEMBL6515065 | 0.83 | TSHR (0.55) | CALM1CAMKK2TSHRHSD17B10PTGES | |
| SCHEMBL14027662 | 0.80 | CALM1 (0.97) | CALM1CAMKK2TSHRHSD17B10KDM4E | |
| SCHEMBL6518349 | 0.80 | TSHR (0.54) | CALM1CAMKK2TSHRHSD17B10PTGES | |
| SCHEMBL15462282 | 0.79 | TSHR (0.57) | CALM1CAMKK2TSHRHSD17B10PTGES | |
| SCHEMBL6511831 | 0.79 | FFAR1 (0.57) | TSHRHSD17B10PTGESTDP1PPARG | |
| SCHEMBL13060673 | 0.78 | CALM1 (0.50) | CALM1CAMKK2TSHRHSD17B10KDM4E | |
| SCHEMBL6515378 | 0.77 | FFAR1 (0.52) | TSHRHSD17B10PTGESLTA4HTDP1 | |
| SCHEMBL6509273 | 0.77 | MEP1B (0.53) | CALM1CAMKK2TSHRHSD17B10PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |