Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.58 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 14/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13005446 | 0.86 | CALM1 (0.54) | CALM1CAMKK2TSHRKDM4EALDH1A1 | |
| SCHEMBL4823756 | 0.80 | KDM4E (0.65) | CALM1CAMKK2TSHRKDM4EALDH1A1 | |
| SCHEMBL524817 | 0.77 | CALM1 (0.65) | CALM1CAMKK2TSHRKDM4EALDH1A1 | |
| SCHEMBL10039140 | 0.75 | CALM1 (0.52) | CALM1CAMKK2TSHRKDM4EALDH1A1 | |
| SCHEMBL10039134 | 0.75 | CALM1 (0.73) | CALM1CAMKK2TSHRKDM4EALDH1A1 | |
| SCHEMBL13061102 | 0.75 | CALM1 (0.64) | CALM1CAMKK2TSHRKDM4EALDH1A1 | |
| SCHEMBL13060673 | 0.75 | CALM1 (0.50) | CALM1CAMKK2TSHRKDM4EALDH1A1 | |
| SCHEMBL14027662 | 0.74 | CALM1 (0.97) | CALM1CAMKK2TSHRKDM4EALDH1A1 | |
| SCHEMBL4816296 | 0.74 | CYP2D6 (0.56) | CALM1CAMKK2TSHRKDM4EALDH1A1 | |
| SCHEMBL4818525 | 0.74 | TAAR1 (0.54) | CALM1CAMKK2TSHRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |