Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | STAT5B | P51692 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5095964 | 0.85 | BRD4 (0.30) | BRD4 | |
| SCHEMBL18089490 | 0.84 | — | — | |
| SCHEMBL12154966 | 0.83 | L3MBTL1 (0.34) | HDAC8 | |
| SCHEMBL14301796 | 0.83 | — | — | |
| SCHEMBL14587285 | 0.80 | KDM4E (0.33) | — | |
| SCHEMBL20297003 | 0.77 | L3MBTL1 (0.35) | BRD4 | |
| SCHEMBL5865339 | 0.77 | TLR9 (0.33) | BRD4 | |
| SCHEMBL5865337 | 0.77 | TLR9 (0.33) | BRD4 | |
| SCHEMBL15286185 | 0.76 | NPSR1 (0.36) | — | |
| SCHEMBL14587288 | 0.76 | NPSR1 (0.37) | HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7847105-B2 | Methods and compounds for preparing CC-1065 analogs | MEDAREX, INC. (US) | 2010-12-07 | — | — | US | disclosed |
| US-20080281102-A1 | Methods and Compounds For Preparing Cc-1065 Analogs | MEDAREX, INC. (US) | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080281102-A1 | Methods and Compounds For Preparing Cc-1065 Analogs | CCNI, CBR3, CNR1 | HDAC1 4178/4885HDAC8 4373/4885HDAC6 4446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.