Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14587285 | 0.85 | KDM4E (0.33) | AKT1L3MBTL1PAX8KDM4EALDH1A1 | |
| SCHEMBL3694335 | 0.84 | LMNA (0.33) | CYP3A4ALDH1A1 | |
| SCHEMBL3694334 | 0.84 | LMNA (0.33) | CYP3A4ALDH1A1 | |
| SCHEMBL3851116 | 0.81 | SMN1; SMN2 (0.40) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2400850 | 0.81 | SMN1; SMN2 (0.40) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2921603 | 0.79 | NPSR1 (0.39) | NPSR1MEN1KMT2ANPC1HTT | |
| SCHEMBL13061313 | 0.76 | HDAC1 (0.30) | HDAC1HDAC8HDAC6 | |
| SCHEMBL2923486 | 0.75 | SMN1; SMN2 (0.41) | NPSR1MEN1KMT2ANPC1HTT | |
| SCHEMBL31439848 | 0.75 | ADRA2C (0.40) | NPSR1MEN1KMT2ANPC1HTT | |
| SCHEMBL15286185 | 0.74 | NPSR1 (0.36) | NPSR1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179921-B2 | Indoline and tetrahydro-quinolines as prodrugs for tumour treatment | SCHOOL OF PHARMACY, UNIVERSITY OF LONDON (GB) | 2007-02-20 | — | — | US | disclosed |