Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13063203 | 0.89 | PDE4A (0.46) | SMN1; SMN2ALDH1A1MAPK1MAPTKDM4E | |
| SCHEMBL13062965 | 0.88 | PDE4A (0.46) | SMN1; SMN2ALDH1A1MAPK1MAPTKDM4E | |
| SCHEMBL2082801 | 0.85 | SLC2A1 (0.44) | SMN1; SMN2ALDH1A1MAPK1MAPTKDM4E | |
| SCHEMBL13062959 | 0.80 | PDE4A (0.37) | SMN1; SMN2ALDH1A1MAPK1KDM4EL3MBTL1 | |
| SCHEMBL2085020 | 0.75 | CA12 (0.54) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2084783 | 0.75 | CA12 (0.54) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2082946 | 0.72 | SLC2A1 (0.46) | SMN1; SMN2ALDH1A1MAPK1MAPTKDM4E | |
| SCHEMBL12964298 | 0.71 | HSD17B10 (0.52) | SMN1; SMN2ALDH1A1MAPK1MAPTKDM4E | |
| SCHEMBL14468819 | 0.69 | PDE4A (0.61) | SMN1; SMN2ALDH1A1MAPK1MAPTKDM4E | |
| SCHEMBL2084529 | 0.69 | SLC2A1 (0.48) | ALDH1A1MAPTNPSR1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100329998-A1 | NOVEL HETEROCYCLES | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100329998-A1 | NOVEL HETEROCYCLES | UACA, GPR4, CASP4 | SMN1; SMN2 175/4885ALDH1A1 2623/4885MAPK1 772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.