Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 2/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.47 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL179108 | 0.83 | CBFB (0.60) | CBFBPDE10APDE5AAURKAALDH1A1 | |
| SCHEMBL12943824 | 0.81 | CBFB (0.51) | CBFBPDE10AALDH1A1RUNX1HPGD | |
| SCHEMBL125165 | 0.79 | CBFB (0.83) | CBFBPDE10APDE5AAURKAALDH1A1 | |
| SCHEMBL19228819 | 0.77 | CBFB (0.46) | CBFBPDE10AALDH1A1RUNX1ITK | |
| SCHEMBL17525962 | 0.77 | RUNX1 (0.62) | CBFBPDE10APDE5AAURKARUNX1 | |
| SCHEMBL4244107 | 0.75 | METAP2 (0.61) | CBFBNPSR1RUNX1HPGDMAPT | |
| SCHEMBL16838739 | 0.72 | SYK (0.44) | ALDH1A1TSHRNPSR1FDPSHPGD | |
| SCHEMBL17919527 | 0.72 | ALDH1A1 (0.43) | ALDH1A1TSHRTTRFDPSHPGD | |
| SCHEMBL3932091 | 0.72 | AMY1A (0.57) | PDE5AALDH1A1TSHRNPSR1AMY1A | |
| SCHEMBL4244743 | 0.71 | MAPT (0.62) | ALDH1A1HPGDMAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132684-A2 | INHIBITORS OF INV(16) LEUKEMIA | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2010-11-18 | — | — | WO | disclosed |